Foot on the
Biomedical
Accelerator

A cell under a microscope

Foot on the
Biomedical
Accelerator

A cell under a microscope

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An unrivalled arsenal of imaging technologies is helping scientists and clinicians to turn discovery in the lab into new treatments for patients.  

“Our ambition is that within the next ten years, we will have translated at least one project from fundamental knowledge to a new medical treatment.”  

Co-Director Professor Francesco Del Galdo sets out the bold vision of the new Cheney Biomedical Accelerator, an unparalleled environment for addressing key research questions critical to understanding human disease. It brings together clinicians and biological researchers to develop diagnostic techniques and treatments for a range of diseases. 

The vision for the Accelerator grew from a new development in imaging methods which, for the first time, allows us to study the structure, function and interaction of molecules in their native context. We can now examine how a molecule’s structure changes in the complex environments of human cells and tissue. This is precisely where proteins have evolved to work – and where they can go wrong in disease. 

The Accelerator has been purpose-built to fuse the expertise of bioscience and clinical researchers and accelerate the discovery of new medical treatments in areas such as cancer and dementia.  

Bringing people together through a common facility and shared projects is the way to turn knowledge into reality.

This exciting work wouldn't be possible without the exceptional generosity of Peter Cheney (Bacteriology and Biochemistry 1969) and his wife Susan who have donated £11m towards the project. They are long-time donors to Leeds, having supported a wealth of research projects, notably into scleroderma, as well as fellowships to enable researchers from overseas to collaborate with academics at Leeds.  

A couple cut the ribbon to open a new facility

Donors Peter and Susan Cheney cut the ribbon to formally open the new facility

Donors Peter and Susan Cheney cut the ribbon to formally open the new facility

Peter explains his support for the Accelerator: “Through my experience here over the last ten years, when I've seen what the clinicians do on one side and what the fundamental scientists do on the other, I felt there was a bit of a void between the two that we could bridge. I think bringing people together through a common facility and shared projects is the way to turn knowledge into reality. We hope this will accelerate the development of medical treatments that can benefit people in the future.” 

The Cheneys’ gift also supports a PhD scholarship programme to develop a new generation of scientists who can tackle the most challenging problems in biology and medicine. It also funds a programme of events and workshops to enable researchers from medicine and biology to explore potential collaborations.  

“It’s a space designed to spark ideas,” says Professor Del Galdo. “By bringing people together across disciplines, we’re creating a community of researchers who can think differently, start from the right questions, and build on the latest technologies to tackle the unmet clinical needs of our society.”   

The Cheney Biomedical Accelerator – also supported by a £1.1m award from the Wolfson Foundation – brings together a range of new and existing, state-of-the art imaging equipment: 

  • Confocal microscopy which allows researchers to observe live cells, and track the movement and interaction of proteins; 
  • Widefield fluorescent microscopy which uses glowing dyes to allow the study of dynamic processes within live cells across a wide field of vision; 
  • Light sheet microscopy which enables the rapid high-resolution 3D imaging of whole organs and embryos; 
  • Super-resolution microscopy which offers unrivalled insights into cellular mechanisms, revealing structures and details not shown by other techniques; 
  • Flow cytometry which enables the rapid analysis and measurement of thousands of individual cells. 
  • Correlated cryo-light microscopy which allows researchers to locate fluorescently-marked samples within cells and tissues, and study these locations in the electron microscope; 
  • Focused ion beam milling which enables cells and tissues to be made thin enough for high resolution structural studies in the electron microscopes within the Astbury Biostructure laboratory; 

Between them, these represent a combination of technologies unrivalled in the UK, giving researchers multiple ways to explore the biological processes of disease. 

The outside of the Cheney Biomedical Accelerator

The Cheney Biomedical Accelerator was officially opened in October 2025

The Cheney Biomedical Accelerator was officially opened in October 2025

The University Vice-Chancellor talks at the opening of the Cheney Biomedical Accelerator

Vice-Chancellor Shearer West talks at the opening of the Accelerator

Vice-Chancellor Shearer West talks at the opening of the Accelerator

Four individuals stand at the entrance to the new building

Susan and Peter Cheney with Deputy Vice-Chancellor for Research and Innovation Professor Nick Plant, and Professor Karen Birch, Executive Dean of the Faculty of Biology

Susan and Peter Cheney with Deputy Vice-Chancellor for Research and Innovation Professor Nick Plant, and Professor Karen Birch, Executive Dean of the Faculty of Biology

Seeking a kinder cancer treatment  

 A new research project into a complex childhood cancer exemplifies the potential of the Cheney Biomedical Accelerator.  

Ewing Sarcoma is a rare, fast-growing cancer which primarily affects the young. Starting as a growth in the soft tissue around bones, it can quickly invade the bone and spread. Treatment can be long and unpleasant, with the aggressive use of chemotherapy and radiation therapy. Even so, some patients are faced with the need for amputation. The search is on for a gentler way to tackle the disease.    

Researchers from our Faculties of Medicine and Biological Sciences will use the technologies of the Accelerator to explore the molecular complexity of Ewing Sarcomas. This will help them understand how the cancer behaves and how it might respond to treatment – and enable researchers to prioritise proteins for the development of targeted treatments for patients.  

“This project is laying the groundwork for more reliable, personalised and kinder treatments,” says Sue Burchill, Professor of Childhood and Adolescent Cancer Research. “If we can improve how we model the disease in the lab, we can help improve how we treat it, increase the cure rates – and spare more young people from amputations.” 

Pioneering 3D Alzheimer’s image

The Cheneys’ gift has supported the purchase of a Focused Ion Beam microscope, whose high-resolution imaging is capable of creating three-dimensional reconstructions of materials. 

This technology was critical to research by Dr René Frank of the School of Biological Sciences, who created the world’s first 3D images of the molecular structure of the human brain. These showed proteins, the molecular building blocks of life, one millionth of the size of a grain of rice, within the brain    

Using brain samples from a patient who died of Alzheimer’s Disease, the study focused on two proteins known to cause dementia. The study aims to get a deeper understanding of how these proteins form, function and interact – in the hope that new drugs might be developed to disrupt these mechanisms.

The work could have wider implications too, as Dr Frank explains: “This first glimpse of the structure of molecules inside the human brain also sets out an approach that can be applied to understanding other devastating neurological diseases.”